Scientific postdoctoral position in Mass Spectrometry Metabolomics and Lipidomics

 To the next possible start date and limited to 2 years, we are looking for a
 
Scientific postdoctoral position in Mass Spectrometry Metabolomics and Lipidomics
 
Make a difference!

We believe in selecting people based on their abilities, not on their stereotypes. We will strive to give all capable candidates an opportunity, irrespective of their race, genders, nationality or background. We are happy to discuss flexible work patterns if requested, job sharing or other solutions that enable strong candidates to work better.

The mission of the Berlin Institute of Health (BIH) is medical translation: transferring biomedical research findings into novel approaches to personalized prediction, prevention, diagnostics and therapy and, conversely, using clinical observations to develop new research ideas. The aim is to deliver relevant medical benefits to patients and the population at large. The BIH is also committed to establishing a comprehensive translational ecosystem – one that places emphasis on a system-wide understanding of health and disease and that promotes change in the biomedical research culture. The BIH is funded 90 percent by the Federal Ministry of Education and Research (BMBF) and 10 percent by the State of Berlin. The two founding institutions, Charité – Universitätsmedizin Berlin and Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), are independent member entities within the BIH.

You will work as a key member of the Berlin Institute for Health (BIH) Metabolomics Platform (https://www.bihealth.org/en/research/core-facilities/metabolomics/) in Campus Buch, Berlin. The role is centered around planning, conducting and analyzing mass spectrometry-based metabolomics samples to elucidate the mechanisms of disease processes. You will be responsible for sample analysis in translational research projects in collaboration with other research groups, focusing on gut, heart and brain health and their connections. The work is varied and requires someone with a broad interest in both biochemistry and medicine and the ability to independently plan projects, write reports and meet deadlines.

The position requires expertise in design of experiments, mass spectrometry and metabolomics data analysis. Experience in statistical analysis is essential. Knowledge of multivariable modelling would be an advantage, especially as conducted in an R-based computing environment. Your role will be heavily collaborative although there will be an opportunity to conduct your own research within the remit of the aims of the BIH.

Your responsibilities include:

  • To provide chemical, biochemical and laboratory analytical support to the Metabolomics Platform of the BIH (Complex statistical support is largely provided by our bioinformaticians, but you will be expected to conduct basic statistical analyses including PCA and PLSDA yourself as part of the general analysis of data)
  • To collaborate with others to ensure robust data quality and high quality outputs including the writing of scientific papers
  • To continue using existing metabolomics pipelines to further the research of the BIH
  • To develop and implement new analytical methods or pipelines as they are required
  • Contribute to interdisciplinary biomedical projects: support experimental designs; present analysis results to coworkers and collaborators; integrate results with other omics data; contribute to interpretation of results; write scientific papers
  • To work on improving data reproducibility
  • Develop innovative scientific approaches when standard methods are not adequate

Your profile:

  • PhD in metabolomics, biochemistry, analytical chemistry or related field
  • Demonstrated experience of laboratory based metabolomics or mass spectrometry project work, including ability to complete projects to an excellent standard within reasonable timeframes
  • Demonstrated substantial experience in independent mass spectrometry chemical analysis and biochemical and statistical interpretation (experience in metabolomics analysis is a major advantage, as is experience in liquid and gas chromatography)
  • have good written and verbal communication skills in English (German language skills are a plus, but not essential)
  • Advantageous if you are highly numerate with a good understanding of both computational and statistical processes, good knowledge of data processing and analysis of mass-spectrometry data (high and low resolution instruments, MS and MSn including fragmentation analysis, liquid and gas chromatography mass spectrometry is a strong plus)
  • Good knowledge of statistical analysis of omics data, experience of functional analyses, particularly in metabolomics, including multivariate analysis and hierarchical clustering is a major advantage
  • Motivated to succeed with a love of learning and a desire to keep challenging yourself
  • Ability to learn quickly and to synthesize ideas from different subjects
  • Team-orientated with excellent organizational skills including project management and good record keeping is important
  • Have the ability to condense and present scientific results to both scientific and non-specialist audiences

We offer:

  • Remuneration in remuneration group E13 TVöD Bund (East)
  • A full-time position (39 hours/week), initially limited for 2 years
  • Flexible working hours

We live diversity!

The BIH strongly encourages women to apply. Applicants with special needs as well as those of equal standing will be given preference if they are equally qualified.

Please submit your application via the BIH career portal https://jobs.bihealth.org  by 02.10.2020, quoting the reference number WO-18/2020.

Further information on the BIH is available at www.bihealth.org.